The optimal hormonal replacement modality selection for multiple organ procurement from brain-dead organ donors
Identifieur interne : 000C84 ( Main/Exploration ); précédent : 000C83; suivant : 000C85The optimal hormonal replacement modality selection for multiple organ procurement from brain-dead organ donors
Auteurs : Zhibao Mi [États-Unis] ; Dimitri Novitzky [États-Unis] ; Joseph F. Collins [États-Unis] ; David Kc Cooper [États-Unis]Source :
- Clinical Epidemiology [ 1179-1349 ] ; 2014.
Abstract
The management of brain-dead organ donors is complex. The use of inotropic agents and replacement of depleted hormones (hormonal replacement therapy) is crucial for successful multiple organ procurement, yet the optimal hormonal replacement has not been identified, and the statistical adjustment to determine the best selection is not trivial. Traditional pair-wise comparisons between every pair of treatments, and multiple comparisons to all (MCA), are statistically conservative. Hsu’s multiple comparisons with the best (MCB) – adapted from the Dunnett’s multiple comparisons with control (MCC) – has been used for selecting the best treatment based on continuous variables. We selected the best hormonal replacement modality for successful multiple organ procurement using a two-step approach. First, we estimated the predicted margins by constructing generalized linear models (GLM) or generalized linear mixed models (GLMM), and then we applied the multiple comparison methods to identify the best hormonal replacement modality given that the testing of hormonal replacement modalities is independent. Based on 10-year data from the United Network for Organ Sharing (UNOS), among 16 hormonal replacement modalities, and using the 95% simultaneous confidence intervals, we found that the combination of thyroid hormone, a corticosteroid, antidiuretic hormone, and insulin was the best modality for multiple organ procurement for transplantation.
Url:
DOI: 10.2147/CLEP.S71403
PubMed: 25565890
PubMed Central: 4278733
Affiliations:
- États-Unis
- Floride, Maryland, Pennsylvanie
- Pittsburgh, Tampa
- Université de Floride du Sud, Université de Pittsburgh
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Collins</name><affiliation wicri:level="2"><nlm:aff id="af1-clep-7-017">Cooperative Studies Program Coordinating Center, VA Maryland Health Care Systems, Perry Point, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cooperative Studies Program Coordinating Center, VA Maryland Health Care Systems, Perry Point, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Cooper, David Kc" sort="Cooper, David Kc" uniqKey="Cooper D" first="David Kc" last="Cooper">David Kc Cooper</name><affiliation wicri:level="4"><nlm:aff id="af3-clep-7-017">Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><series><title level="j">Clinical Epidemiology</title><idno type="eISSN">1179-1349</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The management of brain-dead organ donors is complex. The use of inotropic agents and replacement of depleted hormones (hormonal replacement therapy) is crucial for successful multiple organ procurement, yet the optimal hormonal replacement has not been identified, and the statistical adjustment to determine the best selection is not trivial. Traditional pair-wise comparisons between every pair of treatments, and multiple comparisons to all (MCA), are statistically conservative. Hsu’s multiple comparisons with the best (MCB) – adapted from the Dunnett’s multiple comparisons with control (MCC) – has been used for selecting the best treatment based on continuous variables. We selected the best hormonal replacement modality for successful multiple organ procurement using a two-step approach. First, we estimated the predicted margins by constructing generalized linear models (GLM) or generalized linear mixed models (GLMM), and then we applied the multiple comparison methods to identify the best hormonal replacement modality given that the testing of hormonal replacement modalities is independent. Based on 10-year data from the United Network for Organ Sharing (UNOS), among 16 hormonal replacement modalities, and using the 95% simultaneous confidence intervals, we found that the combination of thyroid hormone, a corticosteroid, antidiuretic hormone, and insulin was the best modality for multiple organ procurement for transplantation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Novitzky, D" uniqKey="Novitzky D">D Novitzky</name></author><author><name sortKey="Wicomb, Wn" uniqKey="Wicomb W">WN Wicomb</name></author><author><name sortKey="Rose, Ag" uniqKey="Rose A">AG Rose</name></author><author><name sortKey="Cooper, Dk" uniqKey="Cooper D">DK Cooper</name></author><author><name sortKey="Reichart, B" uniqKey="Reichart B">B Reichart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Novitzky, D" uniqKey="Novitzky D">D Novitzky</name></author><author><name sortKey="Cooper, Dk" uniqKey="Cooper D">DK Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Novitzky, D" uniqKey="Novitzky D">D Novitzky</name></author><author><name sortKey="Mi, Z" uniqKey="Mi Z">Z Mi</name></author><author><name sortKey="Sun, Q" uniqKey="Sun Q">Q Sun</name></author><author><name sortKey="Collins, J" uniqKey="Collins J">J Collins</name></author><author><name sortKey="Cooper, Dkc" uniqKey="Cooper D">DKC Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Novitzky, D" uniqKey="Novitzky D">D Novitzky</name></author><author><name sortKey="Cooper, Dkc" uniqKey="Cooper D">DKC Cooper</name></author><author><name sortKey="Rosendale, Jd" uniqKey="Rosendale J">JD Rosendale</name></author><author><name sortKey="Hm Kauffman, Hm" uniqKey="Hm Kauffman H">HM HM Kauffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosendale, Jd" uniqKey="Rosendale J">JD Rosendale</name></author><author><name sortKey="Chabalewski, Fl" uniqKey="Chabalewski F">FL Chabalewski</name></author><author><name sortKey="Mcbride, Ma" uniqKey="Mcbride M">MA McBride</name></author><author><name sortKey="Garrity, Er" uniqKey="Garrity E">ER Garrity</name></author><author><name sortKey="Rosengard, Br" uniqKey="Rosengard B">BR Rosengard</name></author><author><name sortKey="Delmonico, Fl" uniqKey="Delmonico F">FL Delmonico</name></author><author><name sortKey="Kaufmann, Hm" uniqKey="Kaufmann H">HM Kaufmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosendale, Jd" uniqKey="Rosendale J">JD Rosendale</name></author><author><name sortKey="Kauffman, Hm" uniqKey="Kauffman H">HM Kauffman</name></author><author><name sortKey="Mcbride, Ma" uniqKey="Mcbride M">MA McBride</name></author><author><name sortKey="Chabalewski, Fl" uniqKey="Chabalewski F">FL Chabalewski</name></author><author><name sortKey="Zaroff, Jg" uniqKey="Zaroff J">JG Zaroff</name></author><author><name sortKey="Garrity, Er" uniqKey="Garrity E">ER Garrity</name></author><author><name sortKey="Delmonico, Fl" uniqKey="Delmonico F">FL Delmonico</name></author><author><name sortKey="Rosengard, Br" uniqKey="Rosengard B">BR Rosengard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooper, Dk" uniqKey="Cooper D">DK Cooper</name></author><author><name sortKey="Novitzky, D" uniqKey="Novitzky D">D Novitzky</name></author><author><name sortKey="Wicomb, Wn" uniqKey="Wicomb W">WN Wicomb</name></author><author><name sortKey="Basker, M" uniqKey="Basker M">M Basker</name></author><author><name sortKey="Rosendale, Jd" uniqKey="Rosendale J">JD Rosendale</name></author><author><name sortKey="Kauffman, Hm" uniqKey="Kauffman H">HM Kauffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunnett, Cw" uniqKey="Dunnett C">CW Dunnett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunnett, Cw" uniqKey="Dunnett C">CW Dunnett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Jc" uniqKey="Hsu J">JC Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Jc" uniqKey="Hsu J">JC Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edwards, Dg" uniqKey="Edwards D">DG Edwards</name></author><author><name sortKey="Hsu, Jc" uniqKey="Hsu J">JC Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tukey, Jw" uniqKey="Tukey J">JW Tukey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Novitzky, D" uniqKey="Novitzky D">D Novitzky</name></author><author><name sortKey="Mi, Z" uniqKey="Mi Z">Z Mi</name></author><author><name sortKey="Videla, La" uniqKey="Videla L">LA Videla</name></author><author><name sortKey="Collins, Jf" uniqKey="Collins J">JF Collins</name></author><author><name sortKey="Cooper, Dkc" uniqKey="Cooper D">DKC Cooper</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li><li>Maryland</li><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li><li>Tampa</li></settlement><orgName><li>Université de Floride du Sud</li><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Mi, Zhibao" sort="Mi, Zhibao" uniqKey="Mi Z" first="Zhibao" last="Mi">Zhibao Mi</name></region><name sortKey="Collins, Joseph F" sort="Collins, Joseph F" uniqKey="Collins J" first="Joseph F" last="Collins">Joseph F. Collins</name><name sortKey="Cooper, David Kc" sort="Cooper, David Kc" uniqKey="Cooper D" first="David Kc" last="Cooper">David Kc Cooper</name><name sortKey="Novitzky, Dimitri" sort="Novitzky, Dimitri" uniqKey="Novitzky D" first="Dimitri" last="Novitzky">Dimitri Novitzky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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